1397. Bromisovalum

Nomenclature

CAS number: 496-67-3
N-(Aminocarbonyl)-2-bromo-3-methylbutanamide; (α-bromoisovaleryl)urea; 2-monobromoisovalerylurea; α-bromo-β-dimethylpropanoylurea; bromvaletone; B.V.U.; Bromural (Knoll); Bromisoval; Uvaleral; Bromuvan; Somnurol (Synochem); Brovalurea; Dormigene (Pharmacobel); Isobromyl (Clin-Comar-Byla); Alluval (Berlin-Chemie); Pivadorm (Specia).
C6H11BrN2O2; mol wt 223.07.
C 32.31%, H 4.97%, Br 35.82%, N 12.56%, O 14.34%.

Description and references

Prepn from urea and α-bromoisovaleryl bromide: US 914518 (1909). Toxicity: R. I. Mrongovius et al., Clin. Exp. Pharmacol. Physiol. 3, 443 (1976).

Chemical structure

Properties

Practically tasteless needles, mp 147-149°. Sublimes. Slightly sol in cold water, but freely sol in hot water. Readily sol in alcohol, ether and in alkaline solns. LD50 in male mice (mmoles/kg): 3.25 i.p. (Mrongovius).

Therapeutic Category

Sedative, hypnotic.

Keywords

Sedative/Hypnotic; Acylic Ureides