1451. Brovincamine

Nomenclature

CAS number: 57475-17-9
(3α,14β,16α)-11-Bromo-14,15-dihydro-14-hydroxyeburnamenine-14-carboxylic acid methyl ester; cis-11-bromovincamine.
C21H25BrN2O3; mol wt 433.34.
C 58.20%, H 5.81%, Br 18.44%, N 6.46%, O 11.08%.

Description and references

Cerebrovascular agent, vincamine deriv. Prepn: P. Pfaeffli, DE 2458164; idem, US 4146643 (1975, 1979 both to Sandoz). HPLC determn in plasma: R. R. Brodie, L. F. Chasseaud, J. Chromatogr. 228, 413 (1982). Effect on autonomic nervous system in laboratory animals: K. Kushiku et al., J. Pharmacobio-Dyn. 7, 177 (1984). Cardiovascular effects, mechanistic studies: eidem, Clin. Exp. Pharmacol. Physiol. 12, 121 (1985). Mode of action studies: T. Katsuragi et al., Gen. Pharmacol. 15, 43 (1984). Clinical trials in patients with multi-infarct dementia: S. Hagstadius et al., Psychopharmacology 83, 321 (1984).

Chemical structure

Properties

Crystals from isopropanol, mp 214° (dec). [α]D20 +8.7° (1% in CHCl3).

Derivative

Hydrogen fumarate.

Nomenclature

CAS number: 84964-12-5
BV-26-723; Sabromin (Sandoz); Zabromin (Sandoz).
C21H25BrN2O3.C4H4O4; mol wt 549.41.
C 54.65%, H 5.32%, Br 14.54%, N 5.10%, O 20.38%.

Properties

mp 144°. [α]D20 +4.7° (0.388% in H2O).

Therapeutic Category

Vasodilator (peripheral).

Keywords

Vasodilator (Peripheral)