1476. Buformin

Nomenclature

CAS number: 692-13-7
N-Butylimidodicarbonimidic diamide; 1-butylbiguanide; n-butylbiguanide; butyldiguanide; butformin; W-37.
C6H15N5; mol wt 157.22.
C 45.84%, H 9.62%, N 44.54%.

Description and references

Prepn: Shapiro et al., J. Am. Chem. Soc. 81, 3728 (1959); Shapiro, Freedman, US 2961377 (1960 to USV). Toxicity study: Rikimaru et al., J. Antibiot. 18A, 196 (1965).

Chemical structure

Properties

Strong base. Very sol in water.

Derivative

Hydrochloride.

Nomenclature

CAS number: 1190-53-0
Andere (Toyama); Biforon (Meiji); Bigunal (Nikken); Bufonamin (Kaken); Bulbonin (Sankyo); Diabrin (USV); Dibetos (Kodama); Gliporal (Grossmann); Insulamin (Iwaki); Krebon; Panformin (Shionogi); Silubin; Sindiatil; Tidemol (Roche); Ziavetine.
C6H15N5.HCl; mol wt 193.68.
C 37.21%, H 8.33%, N 36.16%, Cl 18.30%.

Properties

Crystals, mp 174-177°. Freely sol in water, alcohol. LD50 i.p. in mice: 380 mg/kg (Rikimaru).

Derivative

Nitrate.
C6H15N5.HNO3; mol wt 220.23.
C 32.72%, H 7.32%, N 38.16%, O 21.79%.

Properties

Crystals from ethanol, dec 125-126°.

Therapeutic Category

Antidiabetic.

Keywords

Antidiabetic; Biguanides