1485. Bunaftine

Nomenclature

CAS number: 32421-46-8
N-Butyl-N-[2-(diethylamino)ethyl]-1-naphthalenecarboxamide; N-butyl-N-[2-(diethylamino)ethyl]-1-naphthamide; bunaphtide; bunaphtine.
C21H30N2O; mol wt 326.48.
C 77.26%, H 9.26%, N 8.58%, O 4.90%.

Description and references

Prepn: M. Giannini, DE 2099894 (1971 to Malesci), C.A. 75, 20222a (1971); M. Giannini et al., Farmaco Ed. Sci. 28, 429 (1973). Pharmacology: A. Ferroni, G. Monticelli, Pharmacol. Res. Commun. 5, 151 (1973). Clinical pharmacokinetics: B. Flouvat et al., Therapie 37, 143 (1982).

Chemical structure

Properties

bp0.1 178°. LD50 i.p. in mice: 122 mg/kg (Giannini et al.).

Derivative

Citrate.

Nomenclature

CAS number: 94157-87-6
Meregon (Malesci).
C21H30N2O.C6H8O7; mol wt 518.60.
C 62.53%, H 7.39%, N 5.40%, O 24.68%.

Therapeutic Category

Antiarrhythmic (class III).

Keywords

Antiarrhythmic