1489. Bunitrolol

Nomenclature

CAS number: 34915-68-9
2-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]benzonitrile; o-[3-(tert-butylamino)-2-hydroxypropoxy]benzonitrile; 1-(2-cyanophenoxy)-2-hydroxy-3-tert-butylaminopropane; Ko-1366.
C14H20N2O2; mol wt 248.32.
C 67.71%, H 8.12%, N 11.28%, O 12.89%.

Description and references

β-Adrenergic blocker. Prepn: H. Koeppe et al., ZA 6803783; eidem, US 3541130 (1968, 1970 both to Boehringer, Ing.). Pharmacology: T. Kimura, Experientia 28, 813 (1972). Studies on absorption, distribution, metabolism, excretion in rats and mice: T. Suzuki, T. Rikihisa, Arzneim.-Forsch. 29, 1707 (1979). Clinical studies: A. Reale et al., J. Int. Med. Res. 4, 338 (1976); J. J. C. Jonker et al., Arzneim.-Forsch. 31, 1140 (1981). Toxicology study: M. Kanda et al., Oyo Yakuri 9, 457, 465, 499 (1975), C.A. 83, 172616 (1975).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 23093-74-5
Betriol (Boehringer, Ing.); Stresson (Boehringer, Ing.).
C14H20N2O2.HCl; mol wt 284.78.
C 59.05%, H 7.43%, N 9.84%, O 11.24%, Cl 12.45%.

Properties

Crystals from ethanol, mp 163-165°. LD50 in mice, rats (mg/kg): 1344-1440, 639-649 orally; 264-265, 222-225 i.p. (Kanda).

Therapeutic Category

Antihypertensive, antiarrhythmic, antianginal.

Keywords

β-Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives