1491. Buparvaquone
Nomenclature
CAS number: 88426-33-9
2-[[4-(1,1-Dimethylethyl)cyclohexyl]methyl]-3-hydroxy-1,4-naphthalenedione; 2-[(4-tert-butylcyclohexyl)methyl]-3-hydroxy-1,4-naphthoquinone; 3-(4-t-butylcyclohexyl)methyl-2-hydroxy-1,4-naphthoquinone; BW-720C; Butalex (Coopers). C21H26O3; mol wt 326.43.
C 77.27%, H 8.03%, O 14.70%.
Description and references
Analog of antimalarial hydroxynaphthoquinones; t-butyl deriv of parvaquone, q.v. Prepn: A. T. Hudson, A. W. Randall, EP 77550; eidem, US 4485117 (1983, 1984 both to Wellcome). In vivo and in vitro antiprotozoal activity: A. T. Hudson et al., Parasitology 90, 45 (1985); N. McHardy et al., Res. Vet. Sci. 39, 29 (1985). Treatment of bovine theileriosis: S. Dhar et al., Vet. Rec. 119, 635 (1986). Efficacy as a chemoimmunoprophylactic of theileriosis: eidem, ibid. 120, 375 (1987).
