1511. Butalbital

Nomenclature

CAS number: 77-26-9
5-(2-Methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-allyl-5-isobutylbarbituric acid; 5-allyl-5-(2-methylpropyl)barbituric acid; 5-isobutyl-5-allylbarbituric acid; alisobumal; allylbarbital; itobarbital; tetrallobarbital; Sandoptal (Sandoz).
C11H16N2O3; mol wt 224.26.
C 58.91%, H 7.19%, N 12.49%, O 21.40%.

Description and references

Prepn: Volwiler, J. Am. Chem. Soc. 47, 2236 (1925).

Chemical structure

Properties

Prisms, mp 138-139°. Slightly bitter taste. Practically insol in water and petr ether. Sol in alcohol, chloroform, ether, acetone, glacial acetic acid, also in solns of fixed alkali hydroxides. A satd aq soln is acid to litmus.

Note

This is a controlled substance (depressant): 21 CFR, 1308.13.

Therapeutic Category

Sedative, hypnotic.

Keywords

Sedative/Hypnotic; Barbituric Acid Derivatives