1527. Butibufen

Nomenclature

CAS number: 55837-18-8
α-Ethyl-4-(2-methylpropyl)benzeneacetic acid; 2-(4-isobutylphenyl)butyric acid; Butilopan (Juste).
C14H20O2; mol wt 220.31.
C 76.32%, H 9.15%, O 14.52%.

Description and references

Prepn: L. Aparicio et al., DE 2505813; eidem, US 4031243 (1976, 1977 both to Juste); J. M. Carretero et al., Eur. J. Med. Chem. 13, 77 (1978). Pharmacology: L. Aparicio, Arch. Int. Pharmacodyn. Ther. 227, 130 (1977). Pharmacokinetics: R. Revilla De Granda et al., An. R. Acad. Farm. 43, 419 (1977), C.A. 88, 83349 (1978). HPLC determination: L. González Tavares et al., Arzneim.-Forsch. 42, 818 (1992).

Chemical structure

Properties

Solid, mp 51-53°. LD50 orally in mice: 810 mg/kg (Carretero).

Therapeutic Category

Anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal); Arylbutyric Acid Derivatives