1722. Calusterone

Nomenclature

CAS number: 17021-26-0
(7β,17β)-17-Hydroxy-7,17-dimethylandrost-4-en-3-one; 7β,17α-dimethyltestosterone; methosarb; U-22550.
C21H32O2; mol wt 316.48.
C 79.70%, H 10.19%, O 10.11%.

Description and references

Synthetic androgen epimeric with bolasterone, q.v. Has been used in treatment of breast cancer. Prepn: Campbell, Babcock, US 3029263; US 3341557 (1962, 1967 both to Upjohn). Clinical studies: Gordan et al., J. Am. Med. Assoc. 219, 483 (1972).

Chemical structure

Properties

Crystals from acetone, mp 127-129°. [α]D +57° (CHCl3). uv max (alcohol): 243 nm.

Note

This is a controlled substance (anabolic steroid): 21 CFR, 1308.13, as defined in 1300.01.