1778. Carazolol

Nomenclature

CAS number: 57775-29-8
1-(9H-Carbazol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol; BM-51052; Conducton (Klinge); Suacron (Praemix).
C18H22N2O2; mol wt 298.38.
C 72.46%, H 7.43%, N 9.39%, O 10.72%.

Description and references

β-Adrenergic blocker. Prepn: H. Leinert et al., DE 2240599 (1974 to Boehringer, Mann.), C.A. 80, 133455a (1974). Comparative study of cardiac action: W. Bartsch et al., Arzneim.-Forsch. 27, 1022 (1977). Initial clinico-pharmacological study: E. Chorianopoulos et al., Herz/Kreislauf 9, 965 (1977), C.A. 88, 164460t (1978). Receptor binding studies: G. Kaiser et al., Arch. Pharmacol. 305, 41 (1978); R. B. Innis et al., Life Sci. 24, 2255 (1979). Use in treatment of stress syndrome in pigs: G. Ballarini, F. Guizzardi, Tieraerztl. Umsch. 36, 171 (1981).

Chemical structure

Derivative

Hydrochloride.
C18H23ClN2O2; mol wt 334.84.
C 64.57%, H 6.92%, Cl 10.59%, N 8.37%, O 9.56%.

Properties

Crystals, mp 234-235°.

Therapeutic Category

Antihypertensive, antianginal, antiarrhythmic.

Therapeutic Category (Veterinary)

Treatment of stress in pigs.

Keywords

β-Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives