1786. Carbarsone

Nomenclature

CAS number: 121-59-5
[4-[(Aminocarbonyl)amino]phenyl]arsonic acid; N-carbamoylarsanilic acid; p-ureidobenzenearsonic acid; N-carbamylarsanilic acid; p-carbamidobenzenearsonic acid; 4-ureido-1-phenylarsonic acid; 4-carbamylaminophenylarsonic acid; p-arsonophenylurea; Amabevan; Ameban; Amibiarson; Arsambide; Carb-O-Sep (Rohm & Haas); Histocarb (Rohm & Haas); Fenarsone; Leucarsone; Aminarsone; Amebarsone (Lilly).
C7H9AsN2O4; mol wt 260.08.
C 32.33%, H 3.49%, As 28.81%, N 10.77%, O 24.61%.

Description and references

Prepd from the sodium salt of arsanilic acid by treatment with potassium cyanate or cyanogen bromide: DE 213155; Stickings, J. Chem. Soc. 1928, 3131; from arsanilic acid by treatment with phosgene: Nakatsu, Kawase, Annu. Rep. Takamine Lab. 8, 44-47 (1956); JP 58 4418 (1958 to Sankyo). Toxicity study: N. A. David et al., Proc. Soc. Exp. Biol. Med. 29, 125 (1931).

Chemical structure

Properties

White powder. mp 174°. Slightly sol in water, alcohol; sol in solns of alkali hydroxides and carbonates. The satd aq soln is acid to litmus. Nearly insol in ether or chloroform.

Therapeutic Category

Antiamebic.

Therapeutic Category (Veterinary)

Antihistomonad in turkeys.

Keywords

Antiamebic