1802. Carbocysteine

Nomenclature

CAS number: 638-23-3
S-(Carboxymethyl)-l-cysteine; (2R)-2-amino-3-[(carboxymethyl)thio]propionic acid; 3-[(carboxymethyl)thio]alanine; AHR-3053; LJ-206; Carbocit (CT); Fluifort (Dompé); Lisomucil (Sanofi-Synthelabo); Loviscol (Wyeth); Muciclar (Pfizer); Mucocis (So.Se.); Mucodyne (Sanofi-Aventis); Mucolase (Lampugnani); Mucolex (Warner-Lambert); Mucopront (Mack, Illert.); Pectox (Italfarmaco); Pulmoclase (UCB); Reomucil (DOC); Rhinathiol (Sanofi-Synthelabo); Siroxyl (Aventis); Transbronchin (Viatris).
C5H9NO4S; mol wt 179.19.
C 33.51%, H 5.06%, N 7.82%, O 35.71%, S 17.89%.

Description and references

Prepn: M. D. Armstrong, J. D. Lewis, J. Org. Chem. 16, 749 (1951); Sch"oberl, Wagner, Z. Physiol. Chem. 304, 97 (1956); Foye, Verderame, J. Am. Pharm. Assoc. 46, 273 (1957); Goodman et al., J. Org. Chem. 23, 1251 (1958). Pharmacology: Huyen-Vu-Ngoc et al., C. R. Seances Soc. Biol. Ses Fil. 160, 1849 (1966); Quevauviller et al., Therapie 22, 485 (1967). Clinical trial in chronic bronchitis: M. Grillage, K. Bernard-Jones, Br. J. Clin. Pract. 39, 395 (1985). Review of pharmacology and clinical uses: D. T. Brown, Drug Intell. Clin. Pharm. 22, 603-608 (1988).

Chemical structure

Properties

mp 204-207°. [α]D24 +0.5° (1N HCl).

Derivative

dl-Form.

Nomenclature

CAS number: 25390-17-4

Properties

Spherical aggregates of needles.

Therapeutic Category

Mucolytic; expectorant.

Keywords

Expectorant; Mucolytic