1860. Carphenazine

Nomenclature

CAS number: 2622-30-2
1-[10-[3-[4-(2-Hydroxyethyl)-1-piperazinyl]propyl]-10H-phenothiazin-2-yl]-1-propanone; 10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]-3-propionylphenothiazine; 2-propionyl-10-[γ-(N′-β-hydroxyethylpiperazino)propyl]phenothiazine; Proketazine (Wyeth).
C24H31N3O2S; mol wt 425.59.
C 67.73%, H 7.34%, N 9.87%, O 7.52%, S 7.53%.

Description and references

Prepn: M. H. Sherlock, N. Sperber, US 2985654 (1961 to Schering); R. F. Tislow et al., US 3023146 (1962 to Am. Home Products).

Chemical structure

Derivative

Dimaleate.

Nomenclature

CAS number: 2975-34-0
C24H31N3O2S.2C4H4O4; mol wt 657.73.
C 58.43%, H 5.98%, N 6.39%, O 24.33%, S 4.88%.

Properties

Yellow crystals from isopropanol, mp 175-177° (Tislow). Also reported as crystals from methanol, mp 165-167° (Sherlock, Sperber).

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Phenothiazines