2032. Cetylpyridinium Chloride

Nomenclature

CAS number: 123-03-5
1-Hexadecylpyridinium chloride; Ceepryn (J. B. Williams); Medilave (Farillon); Merocet (HMR); Pristacin; Pyrisept.
C21H38ClN; mol wt 339.99.
C 74.19%, H 11.27%, Cl 10.43%, N 4.12%.

Description and references

Pharmacology and toxicology: J. Pharmacol. Exp. Ther. 74, 401 (1942). Review of early literature: C. L. Huyck, Am. J. Pharm. 116, 50 (1944). Toxicity data: J. W. Nelson, S. C. Lyster, J. Am. Pharm. Assoc. 35, 89 (1946).

Chemical structure

Derivative

Monohydrate.

Nomenclature

CAS number: 6004-24-6
Dobendan (Cassella-med); Halset (Strohschein).

Properties

White powder, mp 77-83°. Freely sol in water, alcohol, chloroform; very slightly sol in benzene, ether. pH (1% aq soln): 6.0 to 7.0. Surface tension (25°): 43 dyn/cm (0.1% aq soln); 41 dyn/cm (1.0%); 38 dyn/cm (10%). LD50 in rats (mg/kg): 250 s.c.; 6 i.p.; 30 i.v.; 200 orally (Nelson, Lyster).

Use

Pharmaceutic aid (preservative).

Therapeutic Category

Antiseptic; disinfectant.

Therapeutic Category (Veterinary)

Topical antiseptic; disinfectant.

Keywords

Antiseptic/Disinfectant; Quaternary Ammonium Compounds