Description and references

Anti-inflammatory principle obtained from chamazulenogenic compds found in chamomile (Matricaria chamomilla L.), wormwood (Artemisia absinthium L.), and yarrow (Achillea millefolium L., Compositae). Isoln: Ruzicka, Rudolph, Helv. Chim. Acta 9, 118 (1926); Ruzicka, Haagen-Smit, ibid. 14, 1104 (1931). Structure: Sorm et al., Collect. Czech. Chem. Commun. 18, 527 (1953); Meisels, Weizmann, J. Am. Chem. Soc. 75, 3865 (1953); Suchy et al., Collect. Czech. Chem. Commun. 21, 477 (1956). Synthesis: Mangoni, Bandiera, Gazz. Chim. Ital. 90, 947 (1960); White, Winter, Tetrahedron Lett. 1963, 137; D. Mukherjee et al., J. Am. Chem. Soc. 101, 251 (1979). Pharmacology: I. G. Boldina, Farmakol. Toksikol. 29, 672 (1966); I. G. Boldina, M. V. Nazarenko, C.A. 67, 42441h (1967).

Properties

Derivative