2068. Chloracizine

Nomenclature

CAS number: 800-22-6
2-Chloro-10-[3-(diethylamino)-1-oxopropyl]-10H-phenothiazine; 2-chloro-10-(N,N-diethyl-β-alanyl)phenothiazine; 10-(β-diethylaminopropionyl)-2-chlorophenothiazine; 2-chloro-10-(β-diethylaminopropionyl)phenothiazine; chloracysin; chlorocyzine; chlorocizin; khloratsizin; G-020.
C19H21ClN2OS; mol wt 360.90.
C 63.23%, H 5.86%, Cl 9.82%, N 7.76%, O 4.43%, S 8.88%.

Description and references

Prepn: Horclois, Metivier, FR 1060715 (1954 to Rh^one Poulenc); GB 740932 (1955); Zhuravlev, Gritsenko, Zh. Obshch. Khim. 26, 3385 (1956), C.A. 51, 9623h (1957). For other prepns in Russian journals see C.A. 55, 6484b, 9425a (1961).

Chemical structure

Derivative

Hydrochloride.
C19H21ClN2OS.HCl; mol wt 397.36.
C 57.43%, H 5.58%, Cl 17.84%, N 7.05%, O 4.03%, S 8.07%.

Properties

Crystals from isopropanol, mp 168-169°. Sol in water.

Therapeutic Category

Vasodilator (coronary).

Keywords

Vasodilator (Coronary)