2153. p-Chlorophenacyl Bromide

Nomenclature

CAS number: 536-38-9
2-Bromo-1-(4-chlorophenyl)ethanone; 2-bromo-4′-chloroacetophenone; 4-chloro-ω-bromoacetophenone; α-bromo-p-chloroacetophenone.
C8H6BrClO; mol wt 233.49.
C 41.15%, H 2.59%, Br 34.22%, Cl 15.18%, O 6.85%.

Description and references

Prepn from bromoacetyl chloride, chlorobenzene, and AlCl3: Collet, Compt. Rend. 125, 718 (1897); by bromination of p-chloroacetophenone: idem, Bull. Soc. Chim. Fr. [3] 21, 69 (1899). Toxicity study: Dat-Xuong et al., Med. Exp. 11(3), 137 (1964).

Chemical structure

Properties

Needles, mp 96-96.5°. LD50 orally in mice: >2000 mg/kg (Dat-Xuong).

Use

In the prepn of quaternary salts of methenamine and of chlorophenol glyoximes.