2346. Clemizole

Nomenclature

CAS number: 442-52-4
1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole; 1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)benzimidazole; 1-(p-chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole.
C19H20ClN3; mol wt 325.84.
C 70.04%, H 6.19%, Cl 10.88%, N 12.90%.

Description and references

Prepn: D. Jerchel et al., Ann. 575, 162 (1952); GB 703272; M. Schenck, W. Heinz, US 2689853 (both 1954 to Schering A.G.).

Chemical structure

Properties

Crystals from dil alc, mp 167°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 1163-36-6
Allercur (Schering AG).
C19H20ClN3.HCl; mol wt 362.30.
C 62.99%, H 5.84%, Cl 19.57%, N 11.60%.

Properties

White microscopic rods from butanol, mp 239-241°. Sol in water.

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic