2367. Clocinizine

Nomenclature

CAS number: 298-55-5
1-[(4-Chlorophenyl)phenylmethyl]-4-(3-phenyl-2-propenyl)piperazine; 1-(p-chloro-α-phenylbenzyl)-4-cinnamylpiperazine; 1-cinnamyl-4-(4-chlorobenzhydryl)piperazine; cliocinizine.
C26H27ClN2; mol wt 402.96.
C 77.50%, H 6.75%, Cl 8.80%, N 6.95%.

Description and references

Prepn: GB 809760 (1959 to Janssen). HPLC determn in cough-cold preparations: G. Cavazzutti et al., J. Liq. Chromatogr. 18, 227 (1995).

Chemical structure

Derivative

Hydrochloride.

Properties

Crystals, mp 200-201°.

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Piperazines