2369. Clocortolone

Nomenclature

CAS number: 4828-27-7
(6α,11β,16α)-9-Chloro-6-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9-chloro-6α-fluoro-16α-methyl-1,4-pregnadiene-11β,21-diol-3,20-dione.
C22H28ClFO4; mol wt 410.91.
C 64.30%, H 6.87%, Cl 8.63%, F 4.62%, O 15.57%.

Description and references

Prepn: NL 6412708; E. K. Kaspar, R. Philippson, DE 2011559; eidem, US 3729495 (1965, 1971, 1973 all to Schering AG). Clinical trials: Wortmann, Wien. Med. Wochenschr. 122, 701 (1972); Baumann, Praxis 61, 536 (1972).

Chemical structure

Properties

Crystals from methanol-methylene chloride, mp 254° (dec).

Derivative

21-Acetate.

Nomenclature

CAS number: 4258-85-9
SH-818.
C24H30ClFO5; mol wt 452.94.
C 63.64%, H 6.68%, Cl 7.83%, F 4.19%, O 17.66%.

Properties

Crystals from methanol-methylene chloride, mp 252° (dec).

Derivative

21-Pivalate.

Nomenclature

CAS number: 34097-16-0
CL-68; SH-863; Cloderm (Ortho); Purantix (Wander).
C27H36ClFO5; mol wt 495.02.
C 65.51%, H 7.33%, Cl 7.16%, F 3.84%, O 16.16%.

Therapeutic Category

Glucocorticoid.

Keywords

Glucocorticoid