2382. Clomestrone

Nomenclature

CAS number: 4091-75-2
(16α)-16-Chloro-3-methoxyestra-1,3,5(10)-trien-17-one; 16α-chloroestrone 3-methyl ether; Arterolo (Nuovo Cons.); Atheran.
C19H23ClO2; mol wt 318.84.
C 71.57%, H 7.27%, Cl 11.12%, O 10.04%.

Description and references

Prepn: Mueller et al., J. Am. Chem. Soc. 80, 1769 (1958); Mueller, US 2855411 (1958 to Searle); Ravizza, CH 343396 (1959). Alternate route: Labs. Sobio, FR 1350100 (1964).

Chemical structure

Properties

Crystals from chloroform, mp 179-180°. [α]D +161° (chloroform).