2392. Clonixin

Nomenclature

CAS number: 17737-65-4
2-[(3-Chloro-2-methylphenyl)amino]-3-pyridinecarboxylic acid; 2-(3-chloro-o-toluidino)nicotinic acid; 2-(2-methyl-3-chloroanilino)nicotinic acid; 2-(3-chloro-2-methylanilino)nicotinic acid; clonixic acid; CBA-93626; Sch-10304.
C13H11ClN2O2; mol wt 262.69.
C 59.44%, H 4.22%, Cl 13.50%, N 10.66%, O 12.18%.

Description and references

Nonsteroidal anti-inflammatory agent. Prepn: M. H. Sherlock, N. Sperber, BE 679271; eidem, US 3337570 (1965, 1967 both to Schering). Pharmacology: A. S. Watnick et al., Arch. Int. Pharmacodyn. 190, 78 (1971). Metabolism in humans: B. Katchen et al., J. Pharmacol. Exp. Ther. 187, 152 (1973). Clinical evaluation of analgesic activity: J. S. Finch, T. J. DeKornfeld, J. Clin. Pharmacol. 15, 371 (1971). GC determn in plasma: C. Giachetti et al., J. High Resolut. Chromatogr. 13, 789 (1990). Toxicology studies: H. Tanaka et al., Oyo Yakuri 7, 655 (1973), C.A. 80, 44091m (1974).

Chemical structure

Properties

Crystals from isopropyl acetate, mp 233-235°. Extremely bitter taste. LD50 in male mice, rats (mg/kg): 415, 335 orally; 198, 148 i.p.; 296, 325 s.c. (Tanaka).

Derivative

Lysine salt.

Nomenclature

CAS number: 55837-30-4
L-104; Clonix (Medicamenta); Deltar (Osiris); Dolalgial (Pharmainvesti); Dorixina (Roemmers).
C13H11ClN2O2.C6H14N2O2; mol wt 408.88.
C 55.81%, H 6.16%, Cl 8.67%, N 13.70%, O 15.65%.

Therapeutic Category

Analgesic.

Keywords

Analgesic; Non-opioids