2402. Cloranolol
Nomenclature
CAS number: 39563-28-5
1-(2,5-Dichlorophenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol; 1-(tert-butylamino)-3-(2,5-dichlorophenoxy)-2-propanol. C13H19Cl2NO2; mol wt 292.20.
C 53.44%, H 6.55%, Cl 24.27%, N 4.79%, O 10.95%.
Description and references
β-Adrenergic blocker. Prepn: G. Richter, DE 2213044 (1972 to Res. Inst. Pharm. Chem. Hungary), C.A. 78, 15780p (1973). Effect on plasma renin and blood pressure: I. Tenyi, Curr. Ther. Res. 21, 823 (1977). Pharmacology: M. I. K. Fekete et al., Arch. Int. Pharmacodyn. 248, 190 (1980). Electrophysiological characteristics: F. Solti, E. Czako, Int. J. Clin. Pharmacol. Ther. Toxicol. 18, 229 (1980). Clinical-pharmacological evaluation: E. T"or"ok et al., ibid. 200. GC-MS determn in plasma: E. Tomori, E. Elekes, J. Chromatogr. 204, 355 (1981). Multicenter clinical trial: E. T"or"ok et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 23, 650 (1985).
Properties
Crystals, mp 82-83°.Derivative
Hydrochloride.Nomenclature
CAS number: 54247-25-5
GYKI-41099; Tobanum (Gedeon Richter). C13H19Cl2NO2.HCl; mol wt 328.66.
C 47.51%, H 6.13%, Cl 32.36%, N 4.26%, O 9.74%.
Properties
Crystals, mp 210-212°.Therapeutic Category
Antiarrhythmic.
Keywords
β-Adrenergic Blocker; Antiarrhythmic