2410. Clortermine

Nomenclature

CAS number: 10389-73-8
2-Chloro-α,α-dimethylbenzeneethanamine; o-chloro-α,α-dimethylphenethylamine; 1-(o-chlorophenyl)-2-methyl-2-propylamine; 1-(o-chlorophenyl)-2-methyl-2-aminopropane.
C10H14ClN; mol wt 183.68.
C 65.39%, H 7.68%, Cl 19.30%, N 7.63%.

Description and references

Prepn and use as anorexic agent: BE 665244; GB 1066616; Finocchio, Huebner, US 3415937 (1965, 1967, 1968, all to Ciba). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Chemical structure

Properties

bp16 116-118°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 10389-72-7
Su-10568; Voranil (USV).
C10H14ClN.HCl; mol wt 220.14.
C 54.56%, H 6.87%, Cl 32.21%, N 6.36%.

Properties

Crystals from ethanol, mp 245-246°. LD50 orally in rats: 332 ±23 mg/kg (Goldenthal).

Note

This is a controlled substance (stimulant): 21 CFR, 1308.13.

Therapeutic Category

Anorexic.

Keywords

Anorexic; CNS Stimulant