2541. Cortol

Nomenclature

CAS number: 516-38-1
(3α,5β,11β,20S)-Pregnane-3,11,17,20,21-pentol.
C21H36O5; mol wt 368.51.
C 68.44%, H 9.85%, O 21.71%.

Description and references

Isolated from human urine after administration of hydrocortisone or ACTH: Fukushima et al., J. Biol. Chem. 212, 449 (1955).

Chemical structure

Derivative

α-Cortol.

Nomenclature

5β-Pregnane-3α,11β,17,20α,21-pentol.

Properties

Crystals from ethyl acetate, mp 250.5-254°. [α]D26 +23.7° (ethanol).

Derivative

α-Cortol 3,20,21-triacetate.
C27H42O8; mol wt 494.62.
C 65.56%, H 8.56%, O 25.88%.

Properties

Crystals from benzene + cyclohexane, mp 168-170°.

Derivative

β-Cortol.

Nomenclature

5β-Pregnane-3α,11β,17,20β,21-pentol.

Properties

Crystals from methanol, mp 262-264.5°. [α]D25 +33.3° (ethanol).