2754. Cyclothiazide

Nomenclature

CAS number: 2259-96-3
3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide; 6-chloro-3-(2-norbornen-5-yl)-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; Lilly 35483; Aquirel; Anhydron (Lilly); Doburil (Boehringer, Ing.); Fluidil (Adria).
C14H16ClN3O4S2; mol wt 389.88.
C 43.13%, H 4.14%, Cl 9.09%, N 10.78%, O 16.41%, S 16.45%.

Description and references

Prepn: C. W. Whitehead et al., J. Org. Chem. 26, 2814 (1961); E. Müller, K. Hasspacher, US 3275625 (1966 to Boehringer, Ing.). Comprehensive description: C. D. Wentling, Anal. Profiles Drug Subs. 1, 65-77 (1972).

Chemical structure

Properties

Crystals from dil alc, mp 234°.

Therapeutic Category

Diuretic; antihypertensive.

Therapeutic Category (Veterinary)

Diuretic.

Keywords

Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs