2806. Daltroban

Nomenclature

CAS number: 79094-20-5
4-[2-[[(4-Chlorophenyl)sulfonyl]amino]ethyl]benzeneacetic acid; [p-[2-(p-chlorobenzenesulfonamido)ethyl]phenyl]acetic acid; BM-13505; SKF-96148.
C16H16ClNO4S; mol wt 353.82.
C 54.31%, H 4.56%, Cl 10.02%, N 3.96%, O 18.09%, S 9.06%.

Description and references

Thromboxane A2-receptor antagonist. Prepn: E. C. Witte et al., DE 3000377; eidem, US 4443477 (1981, 1984 both to Boehringer, Mann.). Receptor binding study: A. Yanagisawa et al., Eur. J. Pharmacol. 133, 89 (1987). Pharmacological evaluations in animals: D. J. Lefer et al., Arch. Int. Pharmacodyn. 287, 89 (1987); E. F. Smith, III, J. McDonald, Pharmacology 36, 340 (1988); P. L"obel et al., Biomed. Biochim. Acta 47, S 86 (1988). GC determn in biological fluids: V. Uebis, J. Chromatogr. 419, 345 (1987).

Chemical structure

Therapeutic Category

Antithrombotic.

Keywords

Antithrombotic; Thromboxane A2-Receptor Antagonist