2890. Demexiptiline

Nomenclature

CAS number: 24701-51-7
5H-Dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime.
C18H18N2O; mol wt 278.35.
C 77.67%, H 6.52%, N 10.06%, O 5.75%.

Description and references

Prepn: S. Schütz et al., DE 1247302; eidem, US 3963778 (1967, 1976 both to Bayer). Synthesis and pharmacological properties: G. Aichinger et al., Arzneim.-Forsch. 19, 838 (1969); S. Rossi et al., Farmaco Ed. Sci. 24, 685 (1969).

Chemical structure

Properties

Colorless oil.

Derivative

Hydrochloride.

Nomenclature

CAS number: 18059-99-9
LM-2909; Deparon (Aron).
C18H18N2O.HCl; mol wt 314.81.
C 68.67%, H 6.08%, N 8.90%, O 5.08%, Cl 11.26%.

Properties

Crystals from isopropanol, mp 232-233°. LD50 in rats (mg/kg): 330 orally, 25 i.v. (Rossi).

Therapeutic Category

Antidepressant.

Keywords

Antidepressant; Tricyclics