Recombinant fusion protein consisting of the catalytic and translocation domains of diphtheria toxin fused to interleukin 2, q.v. Immunotoxin that selectively targets eukaryotic cells expressing the interleukin 2 receptor. Prepn: D. Williams et al., J. Biol. Chem. 265, 11885 (1990). Clinical evaluation in cutaneous T cell lymphoma: M. Duvic et al., Am. J. Hematol. 58, 87 (1998). Review of development and clinical experience: F. M. Foss et al., Curr. Top. Microbiol. Immunol. 234, 63-81 (1998).
Antineoplastic.
Antineoplastic; Immunotoxins