2895. Denopterin

Nomenclature

CAS number: 22006-84-4
N-[4-[[1-(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)ethyl]methylamino]benzoyl]-l-glutamic acid; 9,10-dimethylpteroylglutamic acid; N10,9-dimethylfolic acid; Dimetfol.
C21H23N7O6; mol wt 469.45.
C 53.73%, H 4.94%, N 20.89%, O 20.45%.

Description and references

Prepn: Hultquist et al., J. Am. Chem. Soc. 71, 619 (1949); Hultquist, Smith, GB 667098 (1952 to Am. Cyanamid).

Chemical structure

Properties

Yellow-orange microcrystals. uv max (0.1N NaOH): 253, 305, 365 nm; (0.1N HCl): 315 nm.

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic; Antimetabolites; Folic Acid Analogs/Antagonists