3046. Dichloralphenazone

Nomenclature

CAS number: 480-30-8
1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one compd with 2,2,2-trichloro-1,1-ethanediol(1:2); dichloralantipyrine; Bonadorm (Smith & Nephew); Dormwell (Smith & Nephew); Welldorm (Smith & Nephew).
C15H18Cl6N2O5; mol wt 519.03.
C 34.71%, H 3.50%, Cl 40.98%, N 5.40%, O 15.41%.
[CCl3CH(OH)2]2.C11H12N2O.

Description and references

Prepn: Pfeiffer, Seidel, Z. Physiol. Chem. 178, 97 (1928). GLC determn in pharmaceutical formulation: F. M. Plakogiannis, A. M. Saad, J. Pharm. Sci. 66, 604 (1977). Clinical trial of combination with isometheptene and acetaminophen, q.q.v., in treatment of migraine: S. Diamond, Headache 15, 282 (1976).

Properties

Small prismatic needles from water, mp 68°.

Note

This is a controlled substance (depressant): 21 CFR, 1308.14.

Therapeutic Category

Sedative, hypnotic.

Keywords

Sedative/Hypnotic; Chloral Derivatives