3048. Dichlorisone

Nomenclature

CAS number: 7008-26-6
(11β)-9,11-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione; 9α,11β-dichloro-1,4-pregnadiene-17α,21-diol-3,20-dione; 9α,11β-dichloro analog of prednisolone; Diloderm (Schering); Disoderm (Schering).
C21H26Cl2O4; mol wt 413.33.
C 61.02%, H 6.34%, Cl 17.15%, O 15.48%.

Description and references

Prepn: Robinson et al., J. Am. Chem. Soc. 81, 2191 (1959); Gould et al., US 2894963 (1959 to Schering).

Chemical structure

Properties

Crystals from acetone, dec 238-241°. [α]D20 +134° (pyridine). uv max (methanol): 237 nm (ε 15400).

Derivative

21-Acetate.

Nomenclature

CAS number: 79-61-8
Astroderm (Medix).
C23H28Cl2O5; mol wt 455.37.
C 60.66%, H 6.20%, Cl 15.57%, O 17.57%.

Properties

Crystals from acetone, dec 246-253°. [α]D25 +162° (dioxane). uv max (methanol): 237 nm (ε 15000).

Therapeutic Category

Antipruritic (topical).

Keywords

Antipruritic