Nomenclature
CAS number: 79-43-6
Bichloracetic acid; dichlorethanoic acid; DCA.
C
2H
2Cl
2O
2; mol wt 128.94.
C 18.63%, H 1.56%, Cl 54.99%, O 24.82%.
CHCl
2COOH.
Description and references
Transformation of chloral to dichloroacetic
acid: Wallach, Ann. 173, 288 (1874); Frantzen, Fikentscher, ibid. 623, 68 (1959); Rosenblum et al., Chem. Ind. (London) 1960, 718.
Toxicity: Smyth et al., Arch.
Ind. Hyg. Occup. Med. 4, 119 (1951); P. W.
Stacpoole et al., N. Engl. J. Med. 300, 372 (1979); J. L. Cicmanec et al., Fundam. Appl. Toxicol. 17, 376
(1991). Mutagenicity studies: V. Herbert et al., Am. J. Clin. Nutr. 33, 1179 (1980).
Use in treatment of lactic acidosis: P. W. Stacpoole et al., N. Engl. J. Med. 309, 390 (1983).
Properties
Liquid; pungent odor. d420 1.563. bp 193-194°. Apparently occurs in
two cryst forms, mp 9.7° and -4°. nD22 1.4659. Corrosive. Miscible
with water, alc, ether. LD50 orally in rats: 2.82 g/kg (Smyth).Derivative
Ethyl ester.
C
4H
6Cl
2O
2; mol wt 157.00.
C 30.60%, H 3.85%, Cl 45.16%, O 20.38%.
Properties
Liquid, bp 158.3-158.7°. d420 1.282. nD20 1.4386. Slightly sol in water; miscible with alcohol, ether.Therapeutic Category
Caustic; keratolytic; topical astringent.
Keywords
Astringent; Keratolytic