3071. Dichlorophen

Nomenclature

CAS number: 97-23-4
2,2′-Methylenebis[4-chlorophenol]; 2,2′-dihydroxy-5,5′-dichlorodiphenylmethane; 5,5′-dichloro-2,2′-dihydroxydiphenylmethane; bis[5-chloro-2-hydroxyphenyl]methane; di[5-chloro-2-hydroxyphenyl]methane; dichlorophene; G-4; Anthiphen; Dicestal; Didroxane; Di-phenthane-70; Parabis (Dow); Plath-Lyse (Génévrier); Preventol G-D; Wespuril (Spitzner).
C13H10Cl2O2; mol wt 269.12.
C 58.02%, H 3.75%, Cl 26.35%, O 11.89%.

Description and references

Prepn by adding a CH2O yielding reagent, e.g. aq HCHO, to p-chlorophenol: Gump, Luthy, US 2334408 (1944 to Burton T. Bush). Acute toxicity: T. B. Gaines, R. E. Linder, Fundam. Appl. Toxicol. 7, 299 (1986).

Chemical structure

Properties

Crystals from toluene, mp 177-178°. Practically insol in water. Sparingly sol in toluene. One gram dissolves in 1 g of 95% ethanol, in less than 1 g of ether. Also sol in methanol, isopropyl ether, petr ether. Sol (with decompn) in alkaline aq solns. LD50 in adult male, female rats (mg/kg): 1506, 1683 orally (Gaines, Linder).

Use

Agricultural fungicide; antimicrobial; germicide in soaps, shampoos, etc.

Therapeutic Category

Anthelmintic (Cestodes).

Therapeutic Category (Veterinary)

Anthelmintic, antiprotozoan, fungicide.

Keywords

Anthelmintic (Cestodes)