3132. Difemerine

Nomenclature

CAS number: 80387-96-8
α-Hydroxy-α-phenylbenzeneacetic acid 2-(dimethylamino)-2-methylpropyl ester; 2-(dimethylamino)-1,1-dimethylethyl benzilate.
C20H25NO3; mol wt 327.42.
C 73.37%, H 7.70%, N 4.28%, O 14.66%.

Description and references

Anticholinergic. Prepn: S. G. Kuznetsov, A. G. El'tsov, Zh. Obshch. Khim. 32, 511 (1962), C.A. 58, 470d (1963); C. Hoffmann, FR M3406 (1965 to Labs. U.P.S.A.), C.A. 63, 13163ab (1965). Toxicity: S. N. Golikov, S. G. Kuznetsov, C.A. 61, 8790b (1964). Comparison of side effects with those of atropine: L. Moser, P. V. Lundt, Med. Welt 31, 1795 (1980). Crystal structure: A. Carpy et al., Acta Crystallogr. B35, 882 (1979).

Chemical structure

Properties

Solid, mp 78-78.3°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 70280-88-5
Luostyl (UPSA).
C20H25NO3.HCl; mol wt 363.88.
C 66.01%, H 7.20%, N 3.85%, O 13.19%, Cl 9.74%.

Properties

Crystals from isopropanol, mp 182°.

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic; Antimuscarinic