3137. Difenpiramide

Nomenclature

CAS number: 51484-40-3
N-2-Pyridinyl-[1,1′-biphenyl]-4-acetamide; diphenpyramide; Z-876; Difenax (Zambeletti).
C19H16N2O; mol wt 288.34.
C 79.14%, H 5.59%, N 9.72%, O 5.55%.

Description and references

Prepn: F. Tenconi, R. M. Tagliabue, DE 2325309 (1973 to Zambeletti); L. Molteni et al., US 3868380 (1975). Pharmacological properties: S. Caliari et al., Arzneim.-Forsch. 27, 2086 (1977). Physicochemical profile: A. Trebbi, G. Filippi, Boll. Chim. Farm. 118, 729 (1979). Therapeutic use: C. Ortolani et al., Clin. Ter. 89, 391 (1979).

Chemical structure

Properties

Crystals, mp 122-124°. LD50 in male mice, rats (mg/kg): 2590, 2075 orally; 1421, 1396 i.p. (Caliari).

Therapeutic Category

Anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal)