3141. Difloxacin

Nomenclature

CAS number: 98106-17-3
6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid.
C21H19F2N3O3; mol wt 399.39.
C 63.15%, H 4.80%, F 9.51%, N 10.52%, O 12.02%.

Description and references

Fluoroquinolone antibacterial structurally related to norfloxacin, q.v. Prepn: D. T. W. Chu, EP 131839; idem, US 4730000 (1985, 1988 both to Abbott); D. T. W. Chu et al., J. Med. Chem. 28, 1558 (1985); H. Narita et al., JP Kokai 85 237069 (1985 to Toyama). Antibacterial spectrum in vitro: J. M. Stamm et al., Antimicrob. Agents Chemother. 29, 193 (1986); in vivo: P. B. Fernandes et al., ibid. 201. Activity vs anaerobic bacteria: eidem, J. Antimicrob. Chemother. 18, 693 (1986). HPLC determn in biological fluids: G. R. Granneman, L. T. Sennello, J. Chromatogr. 413, 199 (1987). Pharmacokinetics in humans: G. R. Granneman et al., Antimicrob. Agents Chemother. 30, 689 (1986).

Chemical structure

Derivative

Monohydrochloride.

Nomenclature

CAS number: 91296-86-5
Abbott 56619; A-56619; Dicural (Fort Dodge).
C21H19F2N3O3.HCl; mol wt 435.85.
C 57.87%, H 4.63%, F 8.72%, N 9.64%, O 11.01%, Cl 8.13%.

Properties

Crystals, mp >275°.

Therapeutic Category (Veterinary)

Antibacterial.