Description and references

Chelating agent related to BAL dimercaprol, q.v.. Prepn: N. S. Johary, L. N. Owen, J. Chem. Soc. 1955, 1307; V. E. Petrun'kin, Ukr. Khim. Zh. 22, 603 (1956), C.A. 51, 5692h (1957). Distribution and excretion in rats: B. Gabard, Arch. Toxicol. 39, 289 (1978). Metabolism study: B. Gabard, R. Walser, J. Toxicol. Environ. Health 5, 759 (1979). Use in removal of internally deposited gold: B. Gabard, Br. J. Pharmacol. 68, 607 (1980). Protection of mice vs lethal effects of sodium arsenite: H. V. Aposhian et al., Toxicol. Appl. Pharmacol. 61, 385 (1981). Pharmacokinetics in dogs: P. Wiedemann et al., Biopharm. Drug Dispos. 3, 267 (1982). Anti-lewisite activity and stability: H. V. Aposhian et al., Life Sci. 31, 2149 (1982). Toxicological studies: F. Planas-Bohne et al., Arzneim.-Forsch. 30, 1291 (1980).

Derivative