3212. Dimetacrine

Nomenclature

CAS number: 4757-55-5
N,N,9,9-Tetramethyl-10(9H)-acridinepropanamine; 10-[3-(dimethylamino)propyl]-9,9-dimethylacridan; 5,5-dimethyl-10-dimethylaminopropylacridan; dimethacrine.
C20H26N2; mol wt 294.43.
C 81.59%, H 8.90%, N 9.51%.

Description and references

Prepn: Holm, GB 933875 (1963 to Kefalas), C.A. 60, 510a (1964); Molnar, Wagner-Jauregg, Helv. Chim. Acta 48, 1782 (1965); FR 1438357 (1966 to Siegfried), C.A. 66, 10856k (1967). Pharmacology and metabolism: Schatz et al., Arzneim.-Forsch. 18, 862 (1968); Ishitani et al., Jpn. J. Pharmacol. 20, 432 (1970).

Chemical structure

Properties

Free base, bp1 200°.

Derivative

Hydrochloride.
C20H26N2.HCl; mol wt 330.89.
C 72.60%, H 8.22%, N 8.47%, Cl 10.71%.

Properties

Crystals from abs alc + acetone, mp 151-154°.

Derivative

Tartrate.

Nomenclature

CAS number: 3759-07-7
SD-709; Istonil (Siegfried).

Therapeutic Category

Antidepressant.

Keywords

Antidepressant; Tricyclics