3216. Dimethindene

Nomenclature

CAS number: 5636-83-9
N,N-Dimethyl-3-[1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine; 2-[1-[2-[2-(dimethylamino)ethyl]inden-3-yl]ethyl]pyridine; 3-[α-(2′-pyridyl)ethyl]-2-(β-dimethylaminoethyl)indene; dimethpyrindene.
C20H24N2; mol wt 292.42.
C 82.15%, H 8.27%, N 9.58%.

Description and references

Synthesis: Huebner et al., J. Am. Chem. Soc. 82, 2077 (1960); Huebner, US 2970149 (1961 to Ciba). Pharmacology: W. E. Barrett et al., Toxicol. Appl. Pharmacol. 3, 534 (1961).

Chemical structure

Derivative

Maleate.

Nomenclature

CAS number: 3614-69-5
Fenistil (Novartis).
C20H24N2.C4H4O4; mol wt 408.49.
C 70.57%, H 6.91%, N 6.86%, O 15.67%.

Properties

Crystals, mp 159-161°. LD50 in rats (mg/kg): 26.8 i.v.; 618.2 orally (Barrett).

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Alkylamine Derivatives