3306. Diphemanil Methylsulfate

Nomenclature

CAS number: 62-97-5
4-(Diphenylmethylene)-1,1-dimethylpiperidinium methyl sulfate; p-(α-phenylbenzylidene)-1,1-dimethylpiperidinium methylsulfate; N,N-dimethyl-4-piperidylidene-1,1-diphenylmethane methylsulfate; Prantal (Schering).
C21H27NO4S; mol wt 389.51.
C 64.75%, H 6.99%, N 3.60%, O 16.43%, S 8.23%.

Description and references

Anticholinergic. Prepn: N. Sperber et al., J. Am. Chem. Soc. 73, 5010 (1951); N. Sperber et al., US 2739968 (1956 to Schering). Pharmacological properties and toxicity data: S. Margolin et al., Proc. Soc. Exp. Biol. Med. 78, 576 (1951). Clinical evaluation in treatment of gustatory sweating: O. Laccourreye et al., Laryngoscope 100, 1651 (1990). Clinical pharmacokinetics: A. M. Vidal et al., Eur. J. Clin. Pharmacol. 42, 689 (1992).

Chemical structure

Properties

Crystals, mp 194-195°. Soluble in water. LD50 in rats, mice, guinea pigs (mg/kg): 1107, 64, 404 orally (Margolin).

Therapeutic Category

In treatment of hyperhidrosis.

Keywords

Antimuscarinic