3358. Disofenin

Nomenclature

CAS number: 65717-97-7
N-[2-[[2,6-Bis(1-methylethyl)phenyl]amino]2-oxoethyl]-N-(carboxymethyl)glycine; [[[(2,6-diisopropylphenyl)carbamoyl]methyl]imino]diacetic acid; (2,6-diisopropylacetanilido)iminodiacetic acid; N-(carboxymethyl)-N-[2-(2,6-diisopropylphenyl)amino]-2-oxoethylglycine; DISIDA.
C18H26N2O5; mol wt 350.41.
C 61.70%, H 7.48%, N 7.99%, O 22.83%.

Description and references

Iminodiacetic acid analog. Prepn of acid and 99mTc-complex: M. de Schrijver, DE 2723605; idem, US 4316883 (1977, 1982 both to Solco Basel). High yield synthesis of acid: M. P. Best et al., Aust. J. Chem. 35, 2371 (1982). Biodistribution: G. Subramanian et al., Nuklearmedizin Suppl. 16, 136 (1978). Chromatographic determn of radiochemical purity: A. M. Zimmer et al., Eur. J. Nucl. Med. 7, 88 (1982). Chemical and biological properties: B. Zmbova et al., Appl. Radiat. Isot. 38, 35 (1987). Pharmacokinetics: I. A. Fraser et al., Eur. J. Nucl. Med. 14, 431 (1988); J. E. Love et al., ibid. 436. Clinical evaluation as hepatobiliary imaging agent: R. C. Stadalnik et al., Radiology 140, 797 (1981).

Chemical structure

Properties

White crystals, mp 196-198° (Zmbova). Also reported as crystals from water, mp 191-192.5° (Best); and as mp 166-175° (de Schrijver). Insol in water.

Derivative

99mTc complex.

Nomenclature

99mTc diisopropyl IDA; 99mTc-DISIDA; Hepatolite (DuPont).

Properties

Distribution coefficient (ethylene dichloride/water): 0.0086.

Therapeutic Category

99mTc-complex as diagnostic aid (radioactive imaging agent).

Keywords

Disofenin Complex with 99mTc: Diagnostic Aid (Radioactive Imaging Agent)