3367. Ditazol

Nomenclature

CAS number: 18471-20-0
2,2′-[(4,5-Diphenyl-2-oxazolyl)imino]bisethanol; N-(4,5-diphenyloxazol-2-yl)diethanolamine; 2-[bis(β-hydroxyethyl)amino]-4,5-diphenyloxazole; 2,2′-dihydroxy-N-(4,5-diphenyloxazol-2-yl)diethylamine; diethamphenazol; S-222; Ageroplas (Serono).
C19H20N2O3; mol wt 324.37.
C 70.35%, H 6.21%, N 8.64%, O 14.80%.

Description and references

Prepn: Marchetti et al., J. Med. Chem. 11, 1092 (1968); FR 1538009; E. Marchetti, US 3557135 (1968, 1971 to Ist. Farmacol. Serono). Series of articles on pharmacology and toxicology: L. Caprino et al., Arzneim.-Forsch. 23, 1272-1291 (1973). Metabolism: Marchetti et al., ibid. 1291.

Chemical structure

Derivative

Monohydrate.

Properties

Crystals from ethyl ether-petr ether, mp 96-98°. LD50 in mice, rats (mg/kg): 9621, 11380 orally; 3390, 7770 i.p. (Caprino).

Therapeutic Category

Anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal)