3394. Dobesilate Calcium

Nomenclature

CAS number: 20123-80-2
2,5-Dihydroxybenzenesulfonic acid calcium salt; calcium dobesilate; hydroquinone calcium sulfonate; Dexium (Delalande); Doxium (Carrion).
C12H10CaO10S2; mol wt 418.41.
C 34.45%, H 2.41%, Ca 9.58%, O 38.24%, S 15.33%.

Description and references

Prepn: ES 335945 (1967 to Labs. Esteve), C.A. 69, 106253z (1968); FR M6163; A. Esteve-Subirana, US 3509207 (1968, 1970 both to Labs. OM). Clinical trials: Berson, Praxis 59, 1305 (1970); 61, 52 (1972). Metabolism: A. Benakis et al., Therapie 29, 211 (1974).

Chemical structure

Properties

White, powdery crystals from water, mp >300° (dec). Color deepens to pink upon exposure to air. Very soluble in water and alcohol. Practically insol in ether, benzene, chloroform. LD50 in mice: 700 mg/kg (Esteve-Subirana).

Therapeutic Category

Vasotropic.

Keywords

Vasoprotectant