Nomenclature
CAS number: 577-11-7
Sulfobutanedioic acid 1,4-bis(2-ethylhexyl) ester sodium salt; sulfosuccinic acid 1,4-bis(2-ethylhexyl) ester
S-sodium salt; bis(2-ethylhexyl)sodium sulfosuccinate; dioctyl sodium sulfosuccinate; sodium dioctyl sulfosuccinate; DSS; Aerosol OT (Cyanamid); Colace (Roberts); Comfolax (Searle); Coprola (Dunster); Dioctylal (Continental Pharma); Dioctyl (Medo); Diotilan (Chinoin); Disonate (Lannett); Doxinate (Hoechst); Doxol (Blair); Dulcivac (Harvey); Jamylène (Théraplix); Molatoc; Molcer (Wallace); Nevax; Regutol (Schering-Plough); Soliwax (Concept Pharm.); Velmol (Berlex); Waxsol (Norgine); Yal (Ritter).
C
20H
37NaO
7S; mol wt 444.56.
C 54.03%, H 8.39%, Na 5.17%, O 25.19%, S 7.21%.
Description and references
Prepn: Jaeger, US 2028091; US 2176423 (1936, 1939, both to Am. Cyanamid). Structure and wetting power: Caryl, Ind. Eng. Chem. 33, 731 (1941).
Comprehensive description: S. Ahuja, J. Cohen, Anal. Profiles Drug Subs. 2, 199-219 (1973); 12, 713-720 (1983). For structure see Docusate calcium.
Properties
Available as wax-like solid, usually in rolls
of tissue-thin material; also as 50-75% solns in various solvents.
Soly in water (g/l): 15 (25°), 23 (40°), 30 (50°), 55 (70°). Sol
in CCl4, petr ether, naphtha, xylene, dibutyl phthalate,
liquid petrolatum, acetone, alcohol, vegetable oils. Very sol in
water + alcohol, water + water-miscible organic solvents. Stable
in acid and neutral solns; hydrolyzes in alkaline solns.Note
Ingredient of the laxative Peri-Colace which also contains casanthranol.Derivative
Docusate potassium.
Nomenclature
CAS number: 7491-09-0
Rectalad (Carter-Wallace).
C
20H
37KO
7S; mol wt 460.67.
C 52.14%, H 8.10%, K 8.49%, O 24.31%, S 6.96%.
Use
Sodium salt as pharmaceutic aid (surfactant); as
wetting agent in industrial, pharmaceutical, cosmetic and food applications;
dispersing and solubilizing agent in foods; adjuvant in tablet formation.
Therapeutic Category
Stool softener.
Therapeutic Category (Veterinary)
Stool softener.
Keywords
Laxative/Cathartic