3442. DPQ

Nomenclature

CAS number: 129075-73-6
3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone.
C18H26N2O2; mol wt 302.41.
C 71.49%, H 8.67%, N 9.26%, O 10.58%.

Description and references

Competitive inhibitor of poly (ADP-ribose)polymerase (PARP). Prepn: M. J. Suto et al., EP 355720; eidem, US 5177075 (1990, 1993 both to Warner-Lambert). Use and effects as inhibitior: M. J. L. Eliasson et al., Nat. Med. 3, 1089 (1997); K. Takahashi et al., Brain Res. 829, 46 (1999).

Chemical structure

Properties

Crystals from water, mp 107-109°. Water soluble.

Use

Reagent for inhibition of PARP.