3451. Droprenilamine

Nomenclature

CAS number: 57653-27-7
N-(2-Cyclohexyl-1-methylethyl)-γ-phenylbenzenepropanamine; (±)-N-(3,3-diphenylpropyl)-α-methylcyclohexaneethylamine; droprenylamine.
C24H33N; mol wt 335.53.
C 85.91%, H 9.91%, N 4.17%.

Description and references

Vasodilator with antiarrhythmic and hypotensive activity. Prepn: M. Carissimi et al., DE 2521113 (1976 to Maggioni), C.A. 84, 164388t (1976). Synthesis and pharmacological study: G. Carenini et al., Arzneim.-Forsch. 26, 2127 (1976). Hemodynamic and metabolic effects: R. J. Marshall, J. R. Parratt, Br. J. Pharmacol. 59, 311 (1977). Clinical evaluation: F. Rengo et al., G. Ital. Cardiol. 10, 473 (1980).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 59182-63-7
MG-8926; Valcor (Maggioni).
C24H33N.HCl; mol wt 371.99.
C 77.49%, H 9.21%, N 3.77%, Cl 9.53%.

Properties

Crystals from isopropanol, mp 175-176°. LD50 in mice (mg/kg): 2850 orally; 68 i.p. (Carenini).

Therapeutic Category

Vasodilator (coronary).

Keywords

Vasodilator (Coronary)