3458. DSIP

Description and references

A nonapeptide that shows enhancement and induction of delta (slow-wave) and spindle EEG patterns. Its occurrence was suspected during dialysis of cerebral venous blood of rabbits during sleep induced by electrical stimulation of the thalamus: M. Monnier, L. H"osli, Science 146, 796 (1964). Initial isoln: eidem, Pfluegers Arch. 282, 60 (1965). Isoln, characterization: G. A. Schoenenberger et al., Experientia 28, 919 (1972). Amino acid sequence, synthesis of DSIP and analogs: G. A. Schoenenberger, M. Monnier, Proc. Natl. Acad. Sci. USA 74, 1282 (1977). Solid phase synthesis: Y. P. Shvachkin et al., Zh. Obshch. Khim. 51, 719 (1981), C.A. 95, 43644s (1981). Rapid liquid phase synthesis: S. Nozaki, I. Muramatsu, Bull. Chem. Soc. Jpn. 55, 2165 (1982). HPLC separation: M. Dizaroglu et al., J. Chromatogr. 237, 417 (1982). Effect on human sleep: D. Schneider-Helmert et al., Lancet 1, 1256 (1981); eidem, Int. J. Clin. Pharmacol. Ther. Toxicol. 19, 341 (1981); D. Schneider-Helmert, G. A. Schoenenberger, Experientia 37, 913 (1981).