3479. Dyphylline

Nomenclature

CAS number: 479-18-5
7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione; 7-(2,3-dihydroxypropyl)theophylline; (1,2-dihydroxy-3-propyl)theophylline; glyphylline; glyfyllin; diprophylline; AFI-phyllin; Astmamasit (Showa Yakuhin); Asthmolysin (Kade); Astrophyllin; Circair (Circle); Coronarin; Cor-Theophyllin (Paramedical); Dilor (Savage); Hiphyllin; Hyphylline; Lufyllin (Mallinckrodt); Neostenovasan; Neothylline (Lemmon); Neotilina; Neo-Vasophylline; Neutrafil; Neutraphylline (Dorsey); Prophyllen (Streuli); Silbephylline (Berk); Solufilin; Solufyllin; Theal ampules (Boehringer, Mann.); Thefylan.
C10H14N4O4; mol wt 254.24.
C 47.24%, H 5.55%, N 22.04%, O 25.17%.

Description and references

Prepn: Jones, Maney, US 2575344 (1951 to State Univ. of Iowa); Roth, Arch. Pharm. 292, 234 (1959). Toxicity data: R. A. Al'tshuler, Med. Prom. SSSR 16, 57 (1962), C.A. 61, 6230g (1964).

Chemical structure

Properties

Extremely bitter crystals from alcohol, mp 158°. uv max (0.001% in H2O): 273 nm (A1%1cm 361). Freely sol in water; one gram dissolves in 3 ml H2O at 25°. Soly (g/100 ml): alc 2; chloroform 1. pH (1% aq soln) 6.6 to 7.3. LD50 in mice (mg/kg): 3400 orally; 1430 s.c. (Al'tshuler).

Therapeutic Category

Bronchodilator.

Keywords

Bronchodilator; Xanthine Derivatives