3529. EGTA

Nomenclature

CAS number: 67-42-5
3,12-Bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid; [ethylenebis(oxyethylenenitrilo)]tetraacetic acid; ethylene glycol bis(β-aminoethylether)-N,N,N′,N′-tetraacetic acid.
C14H24N2O10; mol wt 380.35.
C 44.21%, H 6.36%, N 7.37%, O 42.06%.

Description and references

Chelating agent. Prepn: H. Schl"apfer, J. Bindler, US 2709178 (1955 to Geigy). Toxicology: J. E. Wynn et al., Toxicol. Appl. Pharmacol. 16, 807 (1970). Thermal properties: M. F. G. Esteban et al., Thermochim. Acta 62, 267 (1983). Cathodic-stripping determn: M. Ciszkowska, Z. Stojek, Talanta 33, 817 (1986). Use in calcium measurements: J. D. Johnson et al., Am. J. Physiol. 272, C1437 (1997); in heavy metal remobilization from river sediment: K.-C. Yu et al., Toxicol. Environ. Chem. 58, 85 (1997). Review of regulation of Ca+2 concentration in biological systems: S. Robertson, J. D. Potter, Methods Pharmacol. 5, 63-75 (1984).

Chemical structure

Derivative

Disodium salt.

Nomenclature

CAS number: 26082-78-0
C14H22N2Na2O10; mol wt 424.31.
C 39.63%, H 5.23%, N 6.60%, Na 10.84%, O 37.71%.

Properties

LD50 orally in rats: 3.96±0.50 g/kg (Wynn).

Use

Chelator for heavy metals. Reagent for maintaining calcium concentrations.